Table 9.

Correlation Between Tear Cytokines and Clinical Severity Parameters in Dysfunctional Tear Syndrome

Cytokine	Symptom Severity Scores	Schirmer 1 Scores	Corneal Fluorescein Staining Scores	Conjunctival Lissamine Staining Scores
EGF	− 0.25	0.44	− 0.38	− 0.46
	NS	P = 0.003	P = 0.01	P = 0.002
IL-12	0.03	− 0.05	− 0.16	− 0.14
	NS	NS	NS	NS
IFN-γ	0.19	− 0.26	0.34	0.29
	NS	NS	P = 0.02	P = 0.06
IL-10	0.18	− 0.29	0.22	0.43
	NS	P = 0.06	NS	P = 0.004
IL-13	0.15	− 0.05	− 0.12	− 0.1
	NS	NS	NS	NS
IL-8	0.17	− 0.28	0.39	0.34
	NS	P = 0.01	P < 0.01	P = 0.02
MIP-1α	0.18	− 0.3	0.40	0.38
	NS	P = 0.05	P < 0.01	P = 0.01
Rantes	−0.05	0.1	−0.24	−0. 14
	NS	NS	NS	NS
IL-1α	0.20	−0.3	0.33	0.49
	NS	P =0.05	P = 0.03	P = 0.0008
IL-1β	0.19	−0.32	0.39	0.38
	NS	P = 0.04	P < 0.01	P= 0.01
IL-6	0.32	−0.32	0.41	0.38
	P = 0.04	P = 0.04	P < 0.01	P = 0.01
TNF-α	−0.04	− 0.12	0.21	0.11
	NS	P = NS	NS	NS

Numbers are Spearman correlation coefficients; Significant correlations are in bold font; NS = non-significant correlation