Table 2.
Effects of novel psychoactive compounds on serotonin (SERT), dopamine(DAT) and norepinephrine (NET) transporter activity.
| Compound | NET | DAT | SERT |
|---|---|---|---|
| Mephedrone | 5.88±0.07 (511) | 6.08±0.07 (543) | 4.99±0.06 (4943) |
| Methiopropamine | 6.09±0.07 (313) | 6.05±0.07 (577) | 4.14±0.07 (>10000) |
| Methylenedioxy-N-benzylcathinone | 5.37±0.07 (1629) | 6.01±0.07 (637) | 4.53±0.06 (>10000) |
| 5-APB | 6.33±0.07 (180) | 6.30±0.07 (265) | 5.78±0.06 (811) |
| 6-APB | 6.52±0.07 (117) | 6.63±0.07 (150) | 5.26±0.06 (2698) |
| Desoxypipradrol | 6.26±0.07 (213) | 7.30±0.06 (32) | 4.27±0.07 (>10000) |
| 5-iod-2-aminoindane | 6.09±0.07 (311) | 5.61±0.06 (1590) | 5.75±0.06 (879) |
| Benzedrone | 5.50±0.07 (1222) | 5.64±0.06 (1491) | 4.75±0.06 (>10000) |
| Dimethylamylamine | 5.77±0.07 (649) | 4.74±0.06 (>10000) | 3.75±0.13 (>10000) |
| Methylenedioxy-aminoindane | 5.78±0.07 (641) | 5.12±0.06 (4924) | 4.93±0.06 (>10000) |
| Methylenedioxy-aminotetralin | 5.64±0.07 (894) | 5.20±0.06 (4067) | 5.65±0.06 (1104) |
| Naphyrone | 6.70±0.07 (200) | 7.28±0.06 (53) | 6.63±0.06 (235) |
| 1-Naphyrone | 6.27±0.07 (536) | 7.32±0.06 (48) | 6.45±0.06 (352) |
| Methylethcathinone | 5.36±0.07 (1668) | 6.08±0.06 (565) | 5.43±0.06 (1798) |
| Amitriptyline* | 6.14±0.07 (178) | 5.01±0.08 (4638) | 6.80±0.06 (123) |
| Nomifensine* | 7.04±0.07 (26) | 6.90±0.06 (66) | 5.56±0.06 (4731) |
| Cocaine* | 5.20±0.10 (1275) | 6.19±0.06 (249) | 5.62±0.08 (818) |
| (−)-MDMA* | 5.50±0.10 (704) | 5.21±0.06 (2425) | 5.17±0.,08 (2306) |
| (+)-MDMA* | 5.70±0.10 (398) | 5.62±0.06 (897) | 5.56±0.08 (948) |
| (+)-Amphetamine* | 6.20±0.10 (101) | 6.54±0.05 (109) | 4.78±0.09 (5728) |
| Fluoxetine* | 5.20±0.10 (1394) | 5.04±0.06 (3764) | 6.55±0.08 (98) |
Data represent mean pKi +/− S.E.M (N =3) and Ki in nM for inhibitory potencies of various novel psychoactive compounds with comparator data for psychostimulants and antidepressants. Values for comparator compounds (marked *) were obtained from assays performed at the same time as test compounds. Samples of the comparator compounds were obtained from the NIMH-PDSP. Ki values highlighted in bold type indicate the most potent interactions (Ki < 100 nM).