Relationship between instantaneous modulus (Ei) and instantaneous strain (εi) of cortical bone at longitudinal, circumferential and radial directions. Exponential regression was fitted for experimental data with instantaneous strain less than 2% from three orientations: longitudinal direction (Ei = 22.1e−62.4si, R2 = 0.83), circumferential direction (Ei = 8.79e−46.3si, R2 = 0.45), and radial direction (Ei = 6.44e−37.5si, R2 = 0.42).