Figure 1. Anticipated effect of isoform-specific sirtuin activation on various age-related diseases.

Based on the current literature, this figure depicts the potential outcomes associated with individual sirtuin activation (SIRT1–7). The sirtuin isoforms with substantial data indicating either a protective or aggravative role for specific age-related diseases are indicated. There are specific disease states in which there is significant uncertainty in the literature as to whether activation or inhibition of the sirtuin is more beneficial, and these instances are thus classified as “disputed.” In the case of cancer, the tumor-suppressor role of certain sirtuin proteins is dependent on cell and tissue type.