Figure 9. Anti-CCL2 and anti-CD137 also suppress SM1WT1 tumor growth.
Groups of 5 WT mice were inoculated with 5 × 105 SM1WT1 cells. Mice received a first treatment course of vehicle or PLX4720 (20 mg/kg i.p.) daily from day 12 to 16 or cIg or anti-CCL2 (20 μg i.p.) on days 12, 14, 16, and 18 after tumor inoculation. This was sequentially followed by cIg or anti-CD137 (100 μg i.p.) on days 17, 19, 21, and 23 after tumor inoculation. Tumor sizes are represented as the mean ± SEM. Statistical differences in tumor sizes between mice treated with control versus combination therapy for each group were determined by a Mann-Whitney test (*P < 0.05).