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. 2013 Feb 22;123(3):1299–1309. doi: 10.1172/JCI67677

Figure 2. Gd-DTPA and GadoSpin transport along glymphatic pathways.

Figure 2

The average TACs for Gd-DTPA (blue circles) and GadoSpin (red circles) are shown for the (A) pituitary recess, (B) pineal recess, (C) cerebellum, (D) olfactory bulb, (E) aqueduct, and (F) pontine nucleus. The location of each of the ROIs is shown on the sagittal brain icon displayed in the top right corner of each of the graphs. (A and B) It is evident that contrast uptake in the pituitary recess and pineal recess is largely similar for Gd-DTPA and GadoSpin. This confirms that within the proximal portions of the glymphatic pathway, paramagnetic contrast agent transport is largely independent of molecular size. It is also clear that tissue uptake of Gd-DTPA is markedly higher than that observed for GadoSpin in the (C) cerebellum, (E) aqueduct, and (F) pontine nucleus. This confirms that the movement of contrast agent from the subarachnoid/proximal paravascular pathway into and through the brain interstitium is indeed dependent upon molecular size. Data are presented as mean ± SEM.