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. 2013 Feb 14;24(3):419–431. doi: 10.1681/ASN.2012070705

Figure 3.

Figure 3.

The α3129–156 epitope present in HLA-DRB1*15:01 Tg (1501 Tg) mice is not present in C57BL/6 mice possessing I-Ab. (A) Groups of mice immunized with peptide pools (dotted lines) react to several areas, including α3129–156. However, C57BL/6 mice immunized in an identical manner respond (by IFN-γ ELISPOT) to similar areas, with the exception of α3129–156. Each dot represents the response from a mouse (n=4 per group). (B) Groups of 1501 Tg and C57BL/6 mice (n=4 per group) are immunized with either α3129–148 or α3137–156 and are then re-stimulated with either a control peptide, α3129–148 (129) or α3137–156 (137), or recombinant murine α3(IV)NC1. Immunized 1501 Tg mice react to both peptides and to α3(IV)NC1. There is no reactivity in C57BL/6 mice. Results are representative of two independent experiments. Numbers on the x axis represent the α3(IV)NC1 N-terminal number of the re-stimulating 20-mer.