Fig. 3.

Depth of cross-reactive T cell responses elicited by various vaccines. The peptides used for the ELISpot assays were designed to maintain their alignment, so they could be directly compared between strains. For each animal, if a vaccine response was found to a peptide, the cross-reactive potential of the response was assessed by counting how many of the 5 test strains were targeted by the response. For each vaccine, the PBL of a monkey that recognized only one strain (blue) were tallied for all animals in the group. Similarly, PBL populations that recognized 2 of the 5 strains (light blue), 3 of the 5 (purple), 4 of 5 (light green), and all 5 strains (pink) are shown. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)