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. Author manuscript; available in PMC: 2013 Jul 5.
Published in final edited form as: Virology. 2012 Apr 21;428(2):121–127. doi: 10.1016/j.virol.2012.03.012

Fig. 4.

Fig. 4

Vaccine-elicited binding antibody and neutralizing antibody responses. (A) Five weeks post-rAd5 boost serum samples were collected from monkeys vaccinated with either 2-valent or 3-valent mosaic immunogens. Antibodies from these serum samples were assessed for binding to purified BaL.01 and Du156.12 gp120 and 93TH057 gp120 core envelope proteins by ELISA. (B) The sera were also assessed for the presence of neutralizing antibodies to a limited number of Tier 1 and Tier 2 viruses. There was a significant increase in the level of Tier 1 neutralization for each of the 3 strains tested in the 3-valent mosaic group (MN, p-value=0.003, using a non-parametric Wilcoxon rank sum test; MW965, p-value=0.0007; and DJ263, p-value=0.0004).