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. 2013 Feb;5(1):33–44. doi: 10.1177/1759720X12468659

Table 2.

Overview of animal studies.

Study Animal (strain) Treatment Administration Dosage Frequency Age Number Follow up Outcome
Swollen joints Infiltration immune cells Bone Effect
Okamoto et al. [2005] Rats (Lewis) AIA Fenofibrate Oral 10 mg/kg
100 mg/kg
Daily 7 weeks 18 days * *
Castillero et al. [2011] Rats (Wistar) AIA Fenofibrate Oral 300 mg/kg Daily N = 16/16/16 15 days *
Bloxham et al. [1990] Rats (AHH/R)
Rats
(AP1/R2)
AIA
CIA
Clobuzarit Oral 10 mg/kg
30 mg/kg
100 mg/kg
60 mg/kg
Daily N = 5/5/5/5/5/5/5
N = 8/8/8/8/8/8/8
5 days
15 days


*
*
Radiographic assessment 0.97*
Still et al. [2008] Rats
(Wistar)
- Bezafibrate Subcutaneous injection 10 mg/kg Daily 3 months N = 15/15/15 12 weeks Trabecular bone
Cortical bone
Bone mass
0.55*
0.96*
0.13

Outcomes given as effect size (calculated with difference in outcomes for both groups divided by the standard deviation of the outcome).

*

p < 0.05; ↓, reduction, effect size cannot be determined.

AIA, adjuvant-induced arthritis; CIA, collagen-induced arthritis.