Table 2.
Association studies analysing the 25-OH-D serum level and the relapse rate in patients with relapsing–remitting multiple sclerosis.
| Reference | Cohort rovenance | Age (years) mean ± SD | Sample size | Mean duration of follow up (years) | Association with IMT for most patients | Vitamin D supplementation for most patients | Relapse rate with an increase of 50 nmol/liter in 25-OH-D serum level |
|---|---|---|---|---|---|---|---|
| Mowry et al. [2010] | USA (San Francisco and New York) | 15 ± 3 | n = 110 | 1.7 | No | No | −68% |
| Simpson et al. [2010] | Australia (Tasmania) | 44 ± 10 | n = 145 | 3 | Yes | No | −50% |
| Pierrot-Deseilligny et al. [2012] | France (Paris region) | 39 ± 10 | n = 156 | 2.5 | Yes | Yes | −68% |
IMT, first-line immunomodulatory therapy; SD, standard deviation.