Purified human FGF2 does not affect neurite outgrowth in HH20-25 SAGs cultured for 24 hours.
Quantification of the average pixel number for SAG explants (A) and the percentage of caspase-3 positive DF1 cells (B). No significant difference in pixel number was found between control and 1-20 ng/ml FGF2 treated explants (A; ANOVA, p=0.7874). There were significantly fewer caspase-3 positive DF-1 cells in the presence of 1 and 10 ng/ml FGF2 compared to controls (B; ANOVA, p<0.0001), demonstrating that the purified FGF2 protein used in the SAG experiments is bioactive.