Table 3.

Summary of the effects of membrane and protein properties on protein–liposome interactions

Electrostatic/physicochemical changes	βS	γS
Decreasing anionic lipid content	Decreases binding	Decreases binding
Increasing membrane curvature	Increases binding	Increases binding
Increasing POPE content	Minor effect	Minor effect
Increasing cholesterol content	No effect	No effect
Increasing gel-phase content	No effect	No effect
Truncating C-terminus of protein	Increases binding	Increases binding