Table 2.

Summary of studies of the occurrence of FAOD in cases of sudden unexpected death

Study (reference)	No.	Sample	Comments
Boles et al. (16) Maryland and Connecticut	418 SIDS	Retrospective study of SIDS (313), accident or abuse (34), 45 cases with infections	All cases of accident or abuse tested negative, 14 profiles were diagnostic for FAOD or OA (4.5%). FAOD diagnosed were MCAD, VLCAD, LCHAD, and carnitine uptake defect
Chace et al. (77) US and Canada	7058	Retrospective study on filer paper blood spots from infants who died due to unknown cause	66 specimens (0.93%) tested positive, 34.8% cases had MCAD deficiency, 13.6% had VLCAD, 9% had CPT-II and CACT and 6% LCHAD deficiency
Wilcox et al. (78) Oregon	247 SUDI	Retrospective postmortem study on newborn screening Guthrie card of SUDI cases over 5 y	MS/MS analysis found that 1.2% cases of SUDI were due to FAOD