Table 7.

Natural SNP in the PRE

SNP	Sequence	Sites deleted	Sites created
rs201592736	5’-TCGGGTGCCGAGCGAGGTGGGCCGGATCAG-3’	AP2, GC Box (I)a, GATA1, PuF	RARγ, ZEB1
rs200621906	5’-TCGGGTGCCGAGCGGGGTGGGCCAGATCAG-3’	AP2, GC Box (II), SP1 (II)b	ENKTF1, GR/PR,
both	5’-TCGGGTGCCGAGCGAGGTGGGCCAGATCAG-3’	AP2, GC Box (both), PuF, SP1 (II)	ENKTF1, GR/PR, RARγ, ZEB1

^aTwo distinct GC boxes were identified in the wildtype PRE sequence and are designated as “I” and “II”.

^bTwo distinct SP1 sites in addition to the GC boxes were identified in the wildtype PRE sequence and are designated as “I” and “II”.