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. 2013 Feb 26;8(2):e58010. doi: 10.1371/journal.pone.0058010

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© 2013 Taylor et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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A. Determination of IC₅₀ values for hits in the presence of 1 unit (50 nM) of M. mazei topo VI. This resulted in the following IC₅₀ values: 6 μM for 9-aminoacridne; 30 μM for m-amsacrine; 30 μM for suramin; 30 μM for hexylresorcinol; 40 μM for purpurin; 8 μM for quinacrine; and 2 μM for mitoxanthrone. B. Native gel shift assays for the binding of M. mazei topo VI to a 147 bp DNA fragment in the presence of screen hits.