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. 2013 Feb 26;8(2):e58010. doi: 10.1371/journal.pone.0058010

Figure 6. DNA cleavage assays with topoisomerase VI screen hits.

Figure 6

A. Assaying the abilities of screen hits to induce M. mazei topo VI-mediated DNA cleavage with 1 unit topo VI (50 nM). B. Inhibition of S. shibatae topo VI by screen hits. C. Assaying the abilities of screen hits to induce S. shibatae topo VI-mediated DNA cleavage. D. Protection of DNA from ADPNP-induced, S. shibatae topo VI-mediated cleavage by screen hits.