Table 1. Summary of Screen Hits.
| Compound | Target | Approx. IC50 (µM) | Mechanism |
| Novobiocin | DNA gyrase | N.D.* | Aminocoumarin ATPase inhibitor |
| Acriflavinium | DNA gyrase | N.D.* | ATPase inhibitor |
| Ciprofloxacin | DNA gyrase | N.D.* | Fluoroquinolone cleavage-complex stabiliser |
| Gatifloxacin | DNA gyrase | N.D.* | Fluoroquinolone cleavage-complex stabiliser |
| Levofloxacin | DNA gyrase | N.D.* | Fluoroquinolone cleavage-complex stabiliser |
| Lomefloxacin | DNA gyrase | N.D.* | Fluoroquinolone cleavage-complex stabiliser |
| Moxifloxacin | DNA gyrase | N.D.* | Fluoroquinolone cleavage-complex stabiliser |
| Norfloxacin | DNA gyrase | N.D.* | Fluoroquinolone cleavage-complex stabiliser |
| Ofloxacin | DNA gyrase | N.D.* | Fluoroquinolone cleavage-complex stabiliser |
| Perfloxacine Mesylate | DNA gyrase | N.D.* | Fluoroquinolone cleavage-complex stabiliser |
| Surafloxacin | DNA gyrase | N.D.* | Fluoroquinolone cleavage-complex stabiliser |
| Mitoxantrone | DNA gyrase/Topo VI | 12/2 | Cleavage-complex stabiliser/Prevents cleavage |
| Suramin | DNA gyrase/Topo VI | 80/30 | Blocks DNA binding |
| Purpurin | Topo VI | 40 | Blocks DNA binding |
| 9-Aminoacridne | Topo VI | 6 | Prevents DNA cleavage |
| Quinacrine | Topo VI | 8 | Prevents DNA cleavage |
| m-Amsacrine | Topo VI | 30 | Prevents DNA cleavage |
| Hexylresorcinol | Topo VI | 30 | Unknown |
*
Not determined in this study.