Table 1.
mirSNP | Gene | Involved miRNAs | Allele | eQTL | Linkagea | p-value (Myers, A.J. et al)b | p-value (Colantuoni, C. et al)c | p-value (Gibbs, J.R. et al)d |
---|---|---|---|---|---|---|---|---|
rs3087822 |
CRIPT |
hsa-miR-200a-3p, hsa-miR-26b-3p, hsa-miR-29b-1-5p, hsa-miR-335-3p |
A/G |
rs3087822 |
1 |
8.45E-05 |
9.54E-18 |
3.20E-13 |
rs13042 |
FAM82B |
hsa-miR-202-5p, hsa-miR-362-5p, hsa-miR-500b, hsa-miR-1914-5p |
A/Ge |
rs13042/rs4961193 |
1/0.864 |
5.03E-06 |
8.52E-16 |
1.30E-08 |
rs1058381 |
RABEP1 |
hsa-miR-4760-3p |
A/G |
rs1058381/rs1065483 |
1/0.954 |
0.00254 |
7.81E-19 |
2.89E-08 |
rs1058398 | RABEP1 | hsa-miR-134, hsa-miR-3118, hsa-miR-943, hsa-miR-192-3p, hsa-miR-5002-3p | A/G | rs1065483 | 0.955 | 0.00254 | 7.81E-19 | 3.92E-10 |
aLinkage analysis of predicted miRNA-related SNPs and eQTLs in 90 CEU individuals from HapMap project.
bA survey of gene expression of 193 normal human brain tissues (cortex) [22]. The p-values have been adjusted by Bonferroni correction.
cA survey of gene expression of 269 normal human brain tissues (prefrontal cortex) [23]. Genome-wide Bonferroni corrected p = 0.05 (2.6e-12).
dA survey of gene expression of 150 normal human brain tissues (cerebellum, frontal cortex, pons, and temporal cortex) [24].
eAlthough rs13042 has four allelotypes in MirSNP, only A and G alleles have frequencies in populations.