Table 2.
Putative miRNA-related SNPs associated with schizophrenia
| mirSNP | Involved gene | MAFa | Involved miRNAs | Alleleb | SCZ-associated SNP | Linkagec | p value | OR |
|---|---|---|---|---|---|---|---|---|
| rs11178988 |
TBC1D15 |
0.156 |
hsa-miR-145-3p, hsa-miR-3680-3p, hsa-miR-5689, hsa-miR-1294 |
C/T |
rs17110426 |
0.945521 |
4.06E-06 |
0.6449 |
| rs11178989 |
TBC1D15 |
0.156 |
hsa-miR-4501 |
A/C |
rs17110426 |
0.945521 |
4.06E-06 |
0.6449 |
| rs17110432 |
TBC1D15 |
0.167 |
hsa-miR-1193, hsa-miR-335-3p, hsa-miR-29b-2-5p |
A/G |
rs17110426 |
1 |
4.06E-06 |
0.6449 |
| rs11544338 |
FAM117B |
0.305 |
hsa-miR-409-3p, hsa-miR-653 |
A/C/G/T |
rs11544338 |
1 |
5.48E-06 |
0.6511 |
| rs11680951 |
FAM117B |
0.291 |
hsa-miR-516a-3p, hsa-miR-376a-5p, hsa-miR-1287, hsa-miR-145-3p, hsa-miR-5191, hsa-miR-516b-3p |
A/C/G/T |
rs11544338 |
1 |
5.48E-06 |
0.6511 |
| rs6058896 |
DNMT3B |
0.078 |
hsa-miR-30b-5p, hsa-miR-3686, hsa-miR-30c-5p, hsa-miR-4773, hsa-miR-2278, hsa-miR-589-3p |
C/T |
rs6058894 |
0.946365 |
2.31E-05 |
1.584 |
| rs10484565 |
TAP2 |
0.078 |
hsa-miR-3689b-5p, hsa-miR-3177-5p, hsa-miR-3689a-5p, hsa-miR-3689f, hsa-miR-190b, hsa-miR-3689e, hsa-miR-190a |
A/G |
rs10484565 |
1 |
3.58E-05 |
1.448 |
| rs670358 |
CDC42BPG |
0.395 |
hsa-miR-4305, hsa-miR-331-3p, hsa-miR-4638-3p, hsa-miR-4705, hsa-miR-3690, hsa-miR-5195-5p, hsa-miR-4308 |
A/G |
rs670358 |
1 |
4.68E-05 |
0.7677 |
| rs11563929 |
STEAP2 |
0.1 |
hsa-miR-16-2-3p, hsa-miR-195-3p, hsa-miR-3942-5p, hsa-miR-4703-5p, hsa-miR-4766-3p |
G/T |
rs11563929 |
1 |
6.81E-05 |
0.7281 |
| rs16870907 |
TAP2 |
0.047 |
hsa-miR-4760-3p, hsa-miR-330-3p |
C/T |
rs16870907 |
1 |
8.48E-05 |
1.589 |
| rs12178 | ZBTB34 | 0.456 | hsa-miR-1267, hsa-miR-501-5p, hsa-miR-3613-3p, hsa-miR-653 | A/C/G/T | rs12178 | 1 | 9.66E-05 | 1.277 |
Eleven putative miRNA-related SNPs link to SCZ-GWAS SNPs with a significance of p < 0.0001.
aMinor allele frequencies (MAF) are from an HCB population.
bAllele reports are from NCBI.
cLinkage analysis of putative miRNA-related SNPs and SCZ-associated SNPs in 90 Asian individuals from the HapMap project.