Table 1. Results of pooled sensitivity and specificity, before and after adjustment for imperfect reference standard.

POC Test	Sample	Reference Standard	Pooled Parameters	Assuming Perfect Reference Standard (95% CrI)	Assuming Imperfect Reference Standard (95% CrI)	Reported Parameter by Manufacturer
Determine	Serum	TP Specific (n = 11)	Sensitivity	92.03% (87.22, 95.77)	90.04% (80.45, 95.21)	100%
			Specificity	92.68% (87.24, 95.87)	94.15% (89.26, 97.66)	100%
	Whole Blood	TP Specific (n = 15)	Sensitivity	79.54% (71.95, 86.04)	86.32% (77.26, 91.70)	92.30%
			Specificity	98.91% (97.71,99.71)	95.85% (92.42, 97.74)	100%
		TP & non-TP Specific (n = 8)	Sensitivity	77.68% (60.94, 90.40)	47.84% (18.25, 83.18)	NA
			Specificity	98.18% (94.42, 99.93)	97.81% (89.75, 99.79)	NA
SD Bioline	Serum	TP Specific (n = 8)	Sensitivity	87.88% (82.43, 91.80)	87.06% (75.67, 94.50)	99.3%
			Specificity	96.03% (92.67, 98.05)	95.85% (89.89, 99.53)	99.5%
	Whole Blood	TP Specific (n = 13)	Sensitivity	83.78% (80.89, 86.47)	84.50% (78.81, 92.61)	NA
			Specificity	98.39% (97.56, 99.01)	97.95% (92.54, 99.33)	NA
Syphicheck	Serum	TP Specific (n = 7)	Sensitivity	75.96% (63.55, 85.29)	74.48% (56.85, 88.44)	100%
			Specificity	98.51% (96.85, 99.59)	99.14% (96.37, 100.0)	NA
	Whole Blood	TP Specific (n = 12)	Sensitivity	75.12% (70.00,80.48)	74.47% (63.94, 82.13)	NA
			Specificity	99.44% (98.96, 99.81)	99.58% (98.91, 99.96)	NA
Visitect	Serum	TP Specific (n = 7)	Sensitivity	87.32% (79.97, 92.14)	85.13% (72.83, 92.57)	NA
			Specificity	95.76% (92.17, 97.76)	96.45% (91.92, 99.29)	NA
	Whole Blood	TP Specific (n = 14)	Sensitivity	76.22% (69.82, 81.62)	74.26% (53.62, 83.68)	NA
			Specificity	99.33% (98.73, 99.78)	99.43% (98.22, 99.98)	NA

CrI = Credible Interval; “n” refers to the number of data entries per group; NA = Not Available.