Figure 1.

An overlay of the x-ray structures of hCE1 and human AChE.

Panels A and B represent the same structure with the latter image representing a 90 degree rotation to the right. Panel A depicts the view looking down into the active site gorge, whereas panel B has been ‘sliced’ in the horizontal plane to allow visualization of the catalytic amino acids. Panel C represents an enlargement of the gorge entrance and D indicates the overlay of the catalytic serine, histidine and glutamic acid. The white arrows in image B represent areas where the structural overlap is reduced and corresponds to the domains that form the entrance to the active site gorge.