Table 2.

Inhibition of carboxylesterases by cholinesterase inhibitors.

Inhibitor	IC50 (μM)
	hCE1	hiCE	AChE	BChE
Benzil	0.37 ± 0.04	0.33 ± 0.03	>100	>100
Tolserine	>100	>100	1.4 ± 0.1	53.1 ± 20.1
Phenethylcymserine	20.5 ± 10.4	5.6 ± 2.7	1.0 ± 0.2	0.51 ± 0.06
Donepezil	>100	>100	0.022 ± 0.005	7.6 ± 1.3
Tacrine	>100	>100	0.079 ± 0.002	0.034 ± 0.001
Rivastigmine	>100	>100	299 ± 24.6	280 ± 110
Galantamine	>100	>100	1.2 ± 0.4	21.7 ± 4.3
Bis(7)-tacrine	40.5 ± 22.0	23.7 ± 3.5	0.0011 ± 0.0001	0.033 ± 0.003
Acridine	>100	>100	252 ± 80.9	6.9 ± 1.4
ACMA	111 ± 54.5	28.4 ± 11.4	2.0 ± 0.2	2.5 ± 0.9
DEA	99.3 ± 32.0	41.6 ± 15.2	6.9 ± 0.7	2.4 ± 0.5