Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Irreversible inhibition of human CEs by cholinesterase inhibitors
| Inhibitor | Inhibitiona (%) | |
|---|---|---|
| hCE1 | hiCE | |
| Benzil | 0 | 0 |
| BNPP | 99.9 | 99.2 |
| Tolserine | 43.4 | 82.4 |
| Phenethylcymserine | 0 | 64.5 |
| Donepezil | 0 | 0 |
| Tacrine | 0 | 58.7 |
| Rivastigmine | 78.8 | 97.5 |
| Galantamine | 0 | 44.1 |
Indicates the amount of enzyme inhibition after preincubation with inhibitor for 1 hour. Inhibitor was removed by centrifugation through 10kDa cutoff filters and residual enzyme activity determined using o-nitrophenyl acetate as a substrate.
