Table 2.
Gene set enrichment analysis (p-values)
| Cases/Controls | Full OXPHOS |
Complex I |
Complex II/III |
Complex IV |
Complex V |
|
|---|---|---|---|---|---|---|
|
All ischemic
stroke |
1048/1384 | 0.012 | 0.024 | > 0.20 | 0.024 | 0.11 |
| - CE | 241/1384 | > 0.20 | > 0.20 | > 0.20 | > 0.20 | > 0.20 |
| - LA | 223/1384 | > 0.20 | > 0.20 | > 0.20 | > 0.20 | > 0.20 |
| - SV | 197/1384 | 0.091 | 0.008 | > 0.20 | 0.005 | > 0.20 |
|
| ||||||
| All ICH | 928/548 | >0.20 | 0.12 | --- | 0.035 | --- |
| - Lobar ICH | 409/548 | >0.20 | >0.20 | --- | >0.20 | --- |
| - Deep ICH | 430/548 | >0.20 | 0.16 | --- | 0.009 | --- |
Association between gene sets and ischemic stroke (ISGS/SWISS) and ICH (ISGC ICH), with p-values reported from 100,000 permutations against the null.
CE = cardioembolic stroke, ICH = intracerebral hemorrhage, LA = large artery stroke, SV = small vessel stroke, OXPHOS = all structural proteins directly contributing to oxidative phosphorylation complex function, --- = analysis not performed.