Table 3.

Genetic score analysis

	Cases/Controls	Full OXPHOS		Complex I		Complex IV
		OR (95% CI)	p	OR (95% CI)	p	OR (95% CI)	p
All ischemic stroke	1048/1384	1.17 (1.03- 1.33)	0.008	1.06 (1.00-1.12)	0.050	1.05 (0.99-1.12)	0.075
SV only	197/1384	1.16 (1.04- 1.29)	0.007	1.13 (1.01-1.26)	0.027	1.14 (1.02-1.27)	0.018
All ICH	928/548	---	---	---	---	1.08 (1.01-1.17)	0.039
Deep only	430/548	---	---	---	---	1.14 (1.03-1.25)	0.008

Genetic score analysis results in the ISGS/SWISS validation cohort and ISGC ICH extension cohort, performed only on gene sets and subgroups with significant p-values in gene set enrichment analysis. Odds ratios represent risk per unit increase in risk score quintile.

CI = confidence interval, OR = odds ratio, OXPHOS = all structural proteins directly contributing to oxidative phosphorylation complex function, SV = small vessel stroke, --- = analysis not performed.

Nominal p-values are reported for association with ischemic stroke and ICH in the validation and extension cohorts.