Table 2.
Secreted phosphoproteins not likely involved in biomineralization
| Protein | Molecular Function | Phosphorylated Residue(s) | Reference |
|---|---|---|---|
| BMP15 | Growth Factor | GIpSAEVT | [62] |
| Interleukin-6 | Cytokine | ESpSKEAL | [85] |
| PCSK9 | Protease | LRpSEEDG; QApSQELQ | [86] |
| coagulation factor IX | Protease | INpSYECW | [66] |
| Pepsin | Protease | ATpSQELS | [87] |
| Fibrinogen | Cofactor | PGpSSER; ADpSGEGD | [88] |
| Complement C3 | Complement System | DGpSGEVV; IKpSGpSDEVQ | [58] |
| IGFBP1 | Binding Protein | AGpSPEpSPEpSTEIT APpSEEDH; ETpSGEEI |
[64] |
| IGFBP3 | Binding Protein | NFpSSESK | [58] |
| Gastrin | Hormone | RRpSAEDE | [89] |
| APOE | Lipid Binding Protein | GQpSTEEL | [58] |
| Cystatin C | Protease Inhibitor | DApSVEEE | [57] |
| Amyloid precursor protein | Neuronal Protein | VEpSLEQE | [57] |
| 7B2 | Neuropeptide hormone/Chaperone | HFpSDEDK | [90] |
| POMC (ACTH) | Neuropeptide hormone | DEpSAEAF | [91] |
| Chromogranin A | Neuropeptide hormone | EDpSKEAE; GLpSAEPG EKpSGEAT; GKpSGELE RLpSKEWE; PSpSREDS EDpSLEAG |
[57, 92–95] |
| Proenkephalin-A | Neuropeptide hormone | LPpSDEEG; GEpSYpSKE | [57, 96] |
| Secretogranin-1 | Neuropeptide hormone | QVpSEEVK; EDpSpSEE K EDpSpSEEKH; EEpSEEGE EEpSEESN; RApSEEEP PQpSEESW; EEpSEEER KKpSAEFP; YDpSEEPV QEpSGEEA; AGpSQENH EEpSEEER |
[57, 92, 94] |
| Secretogranin-2 | Neuropeptide hormone | QGpSSEDD; RDpSKENI GSpSQETD |
[57, 94] |