Table 2.

Multivariable Cox regression analysis of incident head and neck carcinoma.

Genes	dbSNP	MA	MAF	Hazard Ratio	95%CI	p-uncorrected	snp
MTHFR	rs6696752	A	0.2906	0.579	0.360–0.933	0.0246	s4
RFC1	rs2276888	A	0.4343	0.629	0.422–0.938	0.0230	s43
	rs2306597	A	0.2053	0.515	0.289–0.919	0.0247	s46
	rs9993224	A	0.4309	0.664	0.446–0.988	0.0437	s47
	rs2066786	A	0.4310	0.637	0.427–0.951	0.0273	s48
	rs6851075	G	0.3305	0.560	0.356–0.882	0.0124	s58
	rs3736168	G	0.4947	1.869	1.263–2.764	0.0017	s59
	rs10033019	A	0.4851	1.937	1.310–2.864	0.0009	s60
TYMS	rs2847154	A	0.2349	0.477	0.272–0.836	0.0097	s116
	rs2612081	A	0.2361	0.473	0.270–0.830	0.0090	s119
DHFR	r6151662	A	0.0555	1.857	1.001–3.446	0.0498	S202

CI, confidence interval; MA, minor allele; MAF, minor allele frequency.

Adjusted for age, smoking status, and randomized treatment assignment.