Table 3.
Haplotype-based Cox regression analysis of incident head and neck carcinoma.
| Genes | * Haplotype-Block | HF | HR; 95%CI | p-uncorrected |
|---|---|---|---|---|
| RFC1 | Block 1 | |||
| rs2276888-rs17288757-rs2306597-rs9993224-rs2066786 | ||||
| 11111 (GGGGG) | 0.56242 | Referent | ||
| 21122 (AGGAA) | 0.16761 | 0.814; 0.295–2.245 | 0.6910 | |
| 21222 (AGAAA) | 0.20340 | 0.259; 0.079–0.849 | 0.0257 | |
| 22122 (AAGAA) | 0.05630 | 0.080; 0.005–1.325 | 0.0778 | |
| Block 2 | ||||
| rs13147094-rs2381375-rs3796517-rs17288033-rs2306596 | ||||
| 11111 (GAAGA) | 0.41702 | Referent | ||
| 11121 (GAACA) | 0.10465 | undetermined | -- | |
| 12212 (GGGGC) | 0.34875 | undetermined | -- | |
| 22112 (AGAGC) | 0.11893 | undetermined | -- | |
| Block 3 | ||||
| rs6851075-rs3736168-rs10033019 | ||||
| 111 (AAG) | 0.18011 | 0.388; 0.131–1.152 | 0.0881 | |
| 121 (AGG) | 0.01171 | undetermined | -- | |
| 122 (AGA) | 0.47692 | Referent | ||
| 211 (GAG) | 0.32258 | 0.217; 0.083–0.568 | 0.0019 |
Only haplotypes with frequency greater than 1% are shown.
1 denotes the major allele, 2 the minor allele.
CI, confidence interval; HF, haplotype frequency.
Adjusted for age, smoking status, and randomized treatment assignment.
*
as defined by Haploview v4.1