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. Author manuscript; available in PMC: 2014 Jun 15.
Published in final edited form as: Adv Drug Deliv Rev. 2012 Oct 23;65(6):782–799. doi: 10.1016/j.addr.2012.10.005

Fig. 5.

Fig. 5

Protection against Yersinia pestis challege after immunization. Mice receiving oral boosts of chloroplast-derived F1-V survived longer than mice receiving subcutaneous boosts Animals were challenged with 15 LD50 of Y. pestis CO92 (whole-body LD50, 6.8 × 104 CFU) While control mice had up to 1010 Y. pestis counts in their spleen, survivors had no detectable Y. pestis, confirming 10-log reduction in the mean bacterial burden among survivors. Copyright © American Society for Microbiology, Infection and Immunity (2008) 76: 3640–3650 doi:10.1128/IAI.00050-08 [18].

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