Table 2.

Significant BAL Parameters with Highly or Moderately Replicable Associations with BOS.

Parameter	Direction of Association	HIGH	MOD.
Cell Composition
Neutrophils (5–42)	↑
T-regulatory cells (45, 46)	↓
Mesenchymal Stromal Cells (51–53)	↑
Cytokines, Chemokines, Growth Factors
IL-6 (17, 27–29, 31, 57, 59, 88)	↑
IL-8 (5, 10–12, 18, 19, 23, 25–31, 35, 55–59).	↑
ET-1 (52, 64)	↑
CCL2/MCP-1 (23, 27, 56, 59, 62, 63)	↑
CCL5/RANTES (18, 23, 56, 59)	↑
MIG/CXCL9 (63, 65)	↑
IP-10/CXCL10 (44, 65)	↑
Innate Immune Components
SP-A (74–76)	↓
SLPI (5, 14, 19, 73)	↓
CCSP (20, 68, 69)	↓
Neutrophil Elastase (14, 21, 73, 77, 89)	↑
Alpha Defensins/HNPs (5, 66–69)	↑
Matrix Metalloproteinases
MMP-9 (6, 15, 55, 57–59, 73, 76, 82)	↑
Oxidative Stress
Myeloperoxidase (7, 10, 14, 25, 26, 59)	↑
Oxidized/Reduced Glutathione (7, 26, 84)	↑
Methionine Sulfoxide (7, 14)	↑