Table 2.

Association of plasma sRAGE levels at 6 and 24 hours with time to BOS. PGD: Primary graft dysfunction, ACR: acute cellular rejection, GERD: Gastro-esophageal reflux disease, PASP: Pulmonary artery systolic pressure

Variable	Hazard ratio (95% CI) sRAGE at 6 hours (n=94)	p value	Hazard Ratio (95% CI) sRAGE at 24 hours (n=106)	p value
sRAGE per 1 SD	1.71 (1.12, 2.62)	0.02	1.75 (1.14, 2.68)	0.01
Adjusted for
Grade 3 PGD at 72 hours	1.69 (1.11, 2.57)	0.01	2.23 (1.24, 4.01)	0.01
ACR (per increase in grade by 1)	1.76 (1.61, 1.93)	<0.01	1.68 (1.54, 1.84)	<0.01
Peak FEV1	1.57 (1.03, 2.38)	0.03	1.89 (1.24, 2.90)	<0.01
CBP	1.69 (1.11, 2.58)	0.02	2.08 (1.31, 3.32)	<0.01
Recipient Race	1.70 (1.11, 2.60)	0.01	1.81 (1.14, 2.88)	0.01
Recipient Diagnosis	1.65 (1.08, 2.53)	0.02	1.78 (1.16, 2.73)	0.01
Recipient Sex	1.76 (1.15, 2.67)	0.01	1.88 (1.22, 2.92)	0.01
Recipient Age	1.70 (1.11, 2.61)	0.01	1.73 (1.14, 2.63)	0.01
Donor Sex	1.66 (1.09, 2.54)	0.02	1.71 (1.12, 2.61)	0.01
Donor Age	1.72 (1.12, 2.64)	0.01	1.75 (1.14, 2.67)	0.01
Donor Race	1.60 (0.98, 2.62)	0.06	1.78 (1.15, 2.75)	0.01
Blood (ml) during first 24 hrs	2.02 (1.23, 3.34)	0.01	2.35 (1.41, 3.90)	<0.01
Transplant type	1.66 (1.09, 2.54)	0.02	2.15 (1.36, 3.41)	<0.01
PASP at transplantation	1.73 (1.13, 2.64)	0.01	2.16 (1.29, 3.60)	<0.01
GERD	1.74 (1.13, 2.67)	0.01	1.61 (1.04. 2.49)	0.03
Multivariable model*	1.67 (1.51, 1.84)	<0.01	2.80 (2.39, 3.28)	<0.01

^*adjusted for grade 3 PGD at 72 hrs, diagnosis, ACR, transplant type, peak FEV1. 24 hour model also includes PASP and blood transfusion.