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. Author manuscript; available in PMC: 2014 Apr 1.
Published in final edited form as: Biol Psychiatry. 2012 Nov 20;73(7):622–630. doi: 10.1016/j.biopsych.2012.09.021

Figure 3.

Figure 3

Depletion of Th17 cells in Rorc(γT)+/GFP mice reduces acquisition of learned helplessness. (A) Basal activity of wild-type or Rorc(γT)+/GFP mice was measured in an open field for 30 min. (B–D) Mice were subjected to standard IES, and 24 h later tested with escapable foot shocks. (B) Escape failures after standard IES. Each symbol represents total escape failures in 30 trials for an individual mouse, bars represent group means (n=8–12 mice/group, t-test *p<0.05, df=18, t=2.267). (C) Average escape latency during 5-trial blocks after standard IES. WT and Rorc(γT)+/GFP mice had an average of 19.4±0.4 and 10.9±1.3 sec escape latency, respectively. (n=8–12 mice/group, Mann Whitney *p<0.05). After behavior measurements, the indicated (D) Th cells or immune cells were stained and analyzed by flow cytometry. Bars represent mean ± sem. (n=8–12 mice/group Mann Whitney *p<0.05).