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. Author manuscript; available in PMC: 2014 Feb 21.
Published in final edited form as: Mol Cell. 2012 Dec 27;49(4):657–667. doi: 10.1016/j.molcel.2012.11.020

Figure 4.

Figure 4

ATM activity is required for CtIP-dependent resection initiation. (a) Chromatin was incubated in mock- or CtIP-depleted LSS with buffer, 100 μM ATMi or 5 mM, isolated and probed with the indicated antibodies (b) 100 μM ATMi (+) or DMSO (−) was added to LSS extract treated with PflMI or buffer, and chromatin was isolated after 40 minutes. (c) Chromatin was incubated in HSS in presence of 100 μM ATMi, 100 μM Chk2i (PV1019), or DMSO, isolated and probed with the indicated antibodies. See also Figure S3.