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. Author manuscript; available in PMC: 2014 Mar 27.
Published in final edited form as: Toxicol Lett. 2013 Jan 21;218(1):81–90. doi: 10.1016/j.toxlet.2013.01.009

Fig. 1.

Fig. 1

Concentration-dependent effects of HBCDD on basal and hCG-supported androgen, progesterone, cAMP and cGMP production in Leydig cells. (A and B) Effects on basal (A) and hCG-stimulated (B) androgen (T+DHT) and progesterone (PROG) accumulation in the culture medium. (C and D) Effects on basal (C) and hCG-supported (D) cAMP accumulation in culture medium. Notice the lack of effects on cGMP levels. In this and following figures, cells (250000 in 500 μl/well) were seeded in 24-well plates, and treated during 6 h with increasing HBCDD concentrations in the absence or presence of 0.125 ng/ml hCG. Data shown represents mean ± SEM from 3–4 independent experiments. * p < 0.05 vs. corresponding control (0).