A) Low magnification images of calbindin immunolabeled WT (A, C, E) and Lc/+ (B, D, F) cerebellar slice cultures treated with the JNK inhibitor, SP600125, and the p38 inhibitor, SB 203580, demonstrate that both of these inhibitors increase WT and Lc/+ PC survival when cultures are treated from 0 to 14 DIV. However, the increase in PC survival is not as dramatic as treatment with the cPKC inhibitor Gö6976. G, H) Estimates of total PC numbers in control and drug treated WT and Lc/+ cerebellar slice cultures from 0 to 14 and 7 to 14 DIV (G: SP600125; H: SB 203580). Scale bar 200μm.