Table III.
Replication p-values and unstandardised betas in the NEO consortium of SNPs in MAT2A and SYNJ2 that were identified in the LBC1936 as nominally associated with measures of both NEO and IPIP personality. P-values < 0.05 are highlighted in bold.
| Measure | GENE | Older Cohorts | Younger Cohorts | Combined | |||
|---|---|---|---|---|---|---|---|
| SNP | Beta (SE) | p | Beta (SE) | p | Beta (SE) | p | |
| MAT2A | |||||||
| Openness | rs1446669 | .00 (.19) | .98 | .03 (.11) | .80 | .05 (.08) | .56 |
| SYNJ2 | |||||||
| Neuroticism | rs10455936 | −.08 (.27) | .76 | −0.09 (.15) | .54 | −.13 (.12) | .26 |
| Agreeableness | rs12202135 | −.02 (.23) | .92 | .07 (.14) | .64 | .02 (.11) | .83 |
| Neuroticism | rs9459093 | .01 (.21) | .96 | −.02 (.13) | .86 | .01 (.10) | .91 |
| Agreeableness | rs9459160 | −.26 (.28) | .36 | .15 (.14) | .31 | .10 (.11) | .37 |
| Agreeableness | rs350292 | −.67 (.25) | .01 § | −.17 (.14) | .22 | −.25 (.11) * | .02 |
| Extraversion | rs1744173 | .25 (.23) | .27 | −.08 (.15) | .60 | .00 (.11) | .96 |
| Extraversion | rs350289 | .11 (.25) | .66 | −.13 (.16) | .42 | −.07 (.12) | .58 |
§
p-value = 0.0059
*
8 of 11 cohorts showed beta effect in the same direction; note that the unstandardised beta estimate in LBC1936 was −.93 with a standard error of .36.