Figure 9.

The formation of RCMs, OSMs, and ODMs under normal development and with lesion in the LGN → E pathway is shown here. The RCMs are the most stable since they are fully dependent on local recurrent connections within layer 4. The OSMs are altered more since their formation is dependent on both local recurrent connections as well as feedforward connections from LGN to layer 4. The ODMs are the most affected by lesions since they are primarily affected by LGN to layer 4 connections. (A) The column shows the RCM, OSM, and ODM after 4 million steps. The eye selectivity of the E neurons in layer 4 appears to be evenly balanced between the two eyes. The ODM appears to have more contiguous patches of neurons that respond to only one of the two eyes. The OSM is developed with more patches of iso-orientation domains. (B) The development of ODMs is affected with more E neurons tuned to the left eye compared to the right eye when 25% of RGCs in the right eye are prevented from stimulating the right LGN neurons. The OSMs also show a reorganization of the map albeit without any dramatic changes. The RCMs are still stable. (C) The development of ODMs is more severely affected compared to (B) when 50% of RGCs in the right eye are prevented from stimulating the right LGN neurons. The OSMs still show iso-orientation domains but there is a re-organization of the patches relative to the 25% lesion case. (D) The development of ODMs is even more severely affected compared to (C) when 75% of RGCs in the right eye are prevented from stimulating the right LGN neurons. The RCMs on the other hand do not appear to be that dramatically affected. The OSMs still show some differentiation in its orientation preferences albeit undergoing more re-organization compared to the 50% lesion case.