Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2013 Mar 1;140(5):1079–1089. doi: 10.1242/dev.085720

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

PMC Copyright notice

Fig. 7. — Chromatin interactions of ERα and RIP140 in the mouse mammary gland. (A) Genome browser snapshot of ERα binding events (top) over input control (bottom) at the RIP140 promoter region. Tag count and genomic coordinates are indicated. (B) Heatmap visualisation of raw read counts for ERα ChIP-seq (left) or input control (right) of all 881 identified binding events. A 5-kb window around the top of the peak (arrowhead) is shown. (C) Quantification of signal intensities of binding events as shown in B, depicting ERα (red) and input control (blue) at a 2.5-kb window around the top of the peak region (indicated by arrowhead). (D) Top-enriched motifs for ERα-chromatin binding events. (E) Genomic distributions of ERα binding event, related to the most proximal gene. (F) Heatmap visualization of ERα (red) and RIP140 (blue) binding events as confirmed by Q-PCR. Fold enrichment over IgG control is calculated and shown in a heatmap on log scale. (G,H) Q-PCR analysis of RIP140 expression and other ERα targets in WT/RIP140 KO (G) and WT/RIP140 Tg (H) mammary glands (n=4). ^*P<0.05. Error bars represent s.e.m.