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. 2013 Mar 1;140(5):1100–1110. doi: 10.1242/dev.088989

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© 2013. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial Share Alike License (http://creativecommons.org/licenses/by-nc-sa/3.0), which permits unrestricted non-commercial use, distribution and reproduction in any medium provided that the original work is properly cited and all further distributions of the work or adaptation are subject to the same Creative Commons License terms.

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Fig. 3. — Disrupted organ function and animal physiology in tsh knockdown flies. (A) Secretory rates (nl min^–1) in control (purple) and tsh knockdown (yellow) MpTs. Cyclic adenosine monophosphate (cAMP) and Leucokinin (LK) were added at ∼30 and 60 minutes, respectively (arrows). Basal secretion rates are lower, and the response to LK is abolished in tsh knockdown tubules. (B) Uric acid crystals accumulate in the MpT lumen in the tsh knockdown. (C) Survival rates of control (purple, n=600) and tsh knockdown (yellow, n=900, nine replicates) animals from embryonic to pupal stages. The main lethal phase in tsh knockdown occurs during pupation. (D) Survival rates for control (purple, n=105) and tsh knockdown (yellow, n=140) adults. (E) Control (left) and tsh knockdown (right) 1-week-old adults. tsh knockdown adults have grossly distended abdomens. (F) Wet and dry weight measurements (mg; three flies/measurement) for adults: control (purple, n=13); tsh knockdown (yellow, n=26). Data are for females (equivalent results for males not shown).