Table 4.
Top GO enrichment terms for expression modules
| Module | Size | Rank | p.Bonf | Fraction | Ontology | Term name |
|---|---|---|---|---|---|---|
| 1 |
1520 |
1 |
1.20E-14 |
0.65147 |
CC |
membrane-bounded organelle |
| 1 |
1520 |
2 |
1.90E-14 |
0.65007 |
CC |
intracellular membrane-bounded organelle |
| 2 |
703 |
1 |
1.30E-05 |
0.04885 |
CC |
ribosome |
| 2 |
703 |
2 |
1.50E-05 |
0.07481 |
BP |
translation |
| 3 |
658 |
1 |
0.00018 |
0.16382 |
CC |
extracellular region |
| 4 |
647 |
1 |
0.011 |
0.63711 |
CC |
membrane-bounded organelle |
| 6 |
442 |
1 |
7.60E-07 |
0.27229 |
BP |
response to stress |
| 6 |
442 |
2 |
2.80E-06 |
0.34217 |
BP |
signal transduction |
| 7 |
426 |
1 |
9.40E-07 |
0.18734 |
BP |
immune system process |
| 8 |
407 |
1 |
0.0042 |
0.66755 |
CC |
intracellular membrane-bounded organelle |
| 9 |
387 |
1 |
1.70E-05 |
0.82961 |
CC |
intracellular part |
| 10 |
355 |
1 |
1.80E-05 |
0.07855 |
BP |
ncRNA metabolic process |
| 10 |
355 |
2 |
3.60E-05 |
0.19335 |
CC |
mitochondrion |
| 12 |
306 |
1 |
2.00E-16 |
0.1134 |
CC |
ribosome |
| 12 |
306 |
2 |
4.00E-16 |
0.17182 |
CC |
ribonucleoprotein complex |
| 12 |
306 |
3 |
1.20E-14 |
0.14777 |
BP |
translation |
| 12 |
306 |
4 |
2.30E-14 |
0.09278 |
BP |
viral transcription |
| 13 |
260 |
1 |
0.00041 |
0.025 |
CC |
hemoglobin complex |
| 13 |
260 |
2 |
0.011 |
0.025 |
BP |
heme biosynthetic process |
| 14 |
237 |
1 |
0.014 |
0.61086 |
MF |
protein binding |
| 15 |
118 |
1 |
0.018 |
0.25688 |
BP |
intracellular signal transduction |
| 15 |
118 |
2 |
0.032 |
0.12844 |
BP |
small GTPase mediated signal transduction |
| 16 |
108 |
1 |
1.30E-05 |
0.18478 |
BP |
translation |
| 16 |
108 |
2 |
0.00017 |
0.1087 |
BP |
ribosome biogenesis |
| 17 |
99 |
1 |
2.30E-09 |
0.36957 |
CC |
mitochondrion |
| 18 |
72 |
1 |
3.30E-06 |
0.1791 |
BP |
platelet activation |
| 18 |
72 |
2 |
1.20E-05 |
0.22388 |
BP |
blood coagulation |
| 19 |
60 |
1 |
1.40E-17 |
0.31034 |
MF |
structural constituent of ribosome |
| 19 |
60 |
2 |
2.90E-17 |
0.32759 |
CC |
ribosome |
| 20 |
52 |
1 |
7.10E-23 |
0.32653 |
BP |
type I interferon-mediated signaling pathway |
| 20 |
52 |
2 |
7.10E-23 |
0.32653 |
BP |
cellular response to type I interferon |
| 23 | 32 | 1 | 0.053 | 0.17241 | CC | external side of plasma membrane |
For each module we list the top enriched GO terms. Columns list the module label, module size, rank of the enrichment p-value for that particular module, the Bonferroni-corrected enrichment p-value (the correction is performed with respect to the number of GO terms), fraction of the module genes also in the GO term, GO ontology, and GO term name. Multiple expression modules exhibit significant enrichment. Row shading separates modules for easier reading. The enrichment provides evidence that the modules are biologically meaningful.