Table 5.
Top GO enrichment terms for methylation modules
| Module | Size | Rank | p.Bonf | Fraction | Ontology | Term name |
|---|---|---|---|---|---|---|
| 32 |
1067 |
1 |
4.20E-09 |
0.1875 |
CC |
extracellular region |
| 1 |
1045 |
1 |
8.20E-16 |
0.790123 |
CC |
intracellular |
| 1 |
1045 |
3 |
1.50E-11 |
0.083333 |
CC |
ribonucleoprotein complex |
| 30 |
616 |
1 |
2.50E-21 |
0.34687 |
BP |
anatomical structure development |
| 30 |
616 |
2 |
1.60E-18 |
0.189509 |
BP |
nervous system development |
| 7 |
594 |
1 |
8.30E-10 |
0.157424 |
BP |
immune system process |
| 7 |
594 |
2 |
9.10E-10 |
0.177102 |
MF |
receptor activity |
| 3 |
427 |
1 |
3.20E-12 |
0.259947 |
CC |
extracellular region |
| 12 |
130 |
1 |
0.0032 |
0.075 |
BP |
DNA recombination |
| 2 |
105 |
1 |
1.70E-10 |
0.191919 |
BP |
lymphocyte activation |
| 2 |
105 |
2 |
2.30E-10 |
0.20202 |
BP |
leukocyte activation |
| 2 | 105 | 3 | 3.60E-10 | 0.323232 | BP | immune system process |
For each module we list the top enriched GO terms. Columns list the module label, module size, rank of the enrichment p-value for that particular module, the Bonferroni-corrected enrichment p-value (the correction is performed with respect to the number of GO terms), fraction of the module genes also in the GO term, GO ontology, and GO term name. Multiple methylation modules exhibit significant enrichment. Row shading separates modules for easier reading. Again, the enrichment provides evidence that the modules are biologically meaningful.