Figure 2.

Guideline development process with responsible guideline groups

^*1German Instrument for Methodical Guideline Assessment (Deutsches Instrument zur methodischen Leitlinien-Bewertung, DELBI) (19)

^*2The management of bipolar disorder in adults, children and adolescents, in primary and secondary care, NICE 2006 (20)

^*3Guidelines of the Scottish Intercollegiate Guidelines Network Grading Review Group, Keaney (21), Lowe (22)

^*4Grading of Recommendations Assessment, Development and Evaluation (GRADE) (23)

^*5Literature up to mid-2005

^*6Starting in 2005, modified search using NICE search criteria + search for additional study questions