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. 2012 Mar 13;13(Suppl 2):S1. doi: 10.1186/1471-2105-13-S2-S1

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Copyright ©2012 Wu et al.; licensee BioMed Central Ltd.

This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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An illustration for microarray classification by using integrative expression profiling (IXP) based on network reordering. a) A framework for ACOR-based IXP approach. b) Overlap between Alzheimer's disease (AD) genes from OMIM and AlzGene databases. c-e) AD-specific PPI network layout with average differential expressions for three AD status (incipient, moderate, and severe) vs. control in GSE1297. Node size is gene weight, node color is differential expressions, and 36 I-class seed genes are greenly circled. f) The reordered adjacent matrix of the AD-specific PPI network. g) The corresponding average ACOR-based IXP profiles for the three contrasts.