Table 1.
Participant characteristics for APOE groups.
| PET Sample | CSF Sample | |||
|---|---|---|---|---|
| APOE ε4+ | APOE ε4− | APOE ε4+ | APOE ε4− | |
| N | 52 | 111 | 56 | 109 |
| Mean age (SD), years | 65 (10) | 68 (10)* | 64 (9) | 68 (10)* |
| Gender (M/F) | 14/38 | 38/73 | 16/40 | 37/72 |
| Mean education (SD), years | 16 (3) | 16 (3) | 16 (3) | 16 (3) |
| Mean BMI (SD) | 28 (6) | 28 (6) | 27 (5) | 29 (6)* |
| Diabetes (−/+) | 49/3 | 100/11 | 52/4 | 97/12 |
| Mean MMSE (SD) | 29.1 (1.5) | 29.2 (.97) | 29.3 (1.3) | 29.1 (1.1) |
| Hypertension (−/+) | 35/17 | 61/50 | 40/16 | 58/51* |
| Heart problems (−/+) | 45/7 | 102/9 | 48/8 | 99/11 |
| Depression (−/+) | 43/9 | 97/14 | 47/9 | 96/13 |
| Mean GDS (SD) | 1.1 (1.4) | 1.1 (1.6) | 1.0 (1.4) | 1.1 (1.5) |
| AHA exercise group (−/+) | 39/13 | 86/25 | 43/13 | 87/22 |
| Mean Exercise Score (SD), Met-hrs/wk | 5.07 (7.06) | 5.21 (7.46) | 4.69 (6.45) | 4.52 (6.13) |
| Mean MCBP (SD) | .16 (.26) | .03 (.10)** | -- | -- |
| Mean Aβ42 (SD), pg/mL | -- | -- | 536 (181) | 692 (217)** |
*
p < .05;
**
p < .01.
MMSE=Mini-Mental State Exam; BMI=Body Mass Index; GDS=Geriatric Depression Scale. AHA exercise group represents whether individuals met the American Heart Association’s recommended exercise levels (see text for details) with + indicating those who met recommendations.