Skip to main content
. Author manuscript; available in PMC: 2013 Nov 1.
Published in final edited form as: Biomaterials. 2012 Aug 24;33(33):8632–8640. doi: 10.1016/j.biomaterials.2012.08.005

Fig. 3.

Fig. 3

αvβ3-targeted fumagillin prodrug nanoparticles (αvβ3-Fum-PD NP) localize specifically to the inflamed paws. Arthritis was induced by the i.p. administration of KRN serum. On day 7, at the peak of disease, mice were injected with rhodamine-conjugated αvβ3-Fum-PD NP or non-targeted NP. (a) Sections of paws were examined for NP accumulation (red). FITC lectin (green) was used to label blood vessels (V). The skin also autofluoresces green. (b) Sections of different organs were examined for NP accumulation 1 h after injection. Scale bar = 0.05 mm.