Fig. 7.

Complement activation by α_vβ₃-Fum-PD NPs. Mice were left uninjected (Ctrl) or injected with one dose (1×) or three serial daily doses of Pro-Fum NP (3×). Thirty min after the last injection, mice were sacrificed and plasma obtained for C3a ELISA. Values represent mean ± SEM (n = 3 animals per treatment group). CVF (2 U i.v.), a strong complement activator, was used as a positive control of complement activation. *P < 0.05 compared with Ctrl.