Table 1.
Hematologic parameters in mice treated with nanoparticles.
| Treatment | Hgb (g/dl) | Platelets (103/mm3) | WBC (103/mm3) | Neutrophils (103/mm3) | Lymphocytes (103/mm3) |
|---|---|---|---|---|---|
| No treatment | 12.8 ± 0.6 | 747 ± 51 | 11.2 ± 0.4 | 1.3 ± 0.2 | 9.8 ± 0.3 |
| αvβ3-Ctrl NP (1×) | 13.5 ± 0.2 | 648 ± 14 | 8.8 ± 1.0 | 1.1 ± 0.1 | 7.8 ± 1.0 |
| αvβ3-Ctrl NP (3×) | 12.7 ± 0.3 | 698 ± 22 | 6.4 ± 0.4** | 0.7 ± 0.1 | 5.6 ± 0.4** |
| αvβ3-Fum-PD NP (1×) | 12.2 ± 0.1 | 738 ± 106 | 8.9 ± 0.5 | 1.7 ± 0.5 | 7.1 ± 0.8* |
| αvβ3-Fum-PD NP (3×) | 13.0 ± 0.4 | 874 ± 52 | 7.3 ± 0.4** | 0.9 ± 0.3 | 6.4 ± 0.4** |
| αvβ3-Fum-PD NP (3×)-24 h | 13.1 ± 0.2 | 637 ± 10 | 8.9 ± 0.1 | 0.8 ± 0.3 | 7.8 ± 0.3 |
*
P < 0.05,
**
P < 0.001 compared with no treatment. Values obtained 30 min after the last nanoparticle injection, unless otherwise indicated. n = 12 in the no treatment group; n = 3–4 in the treated groups.