Table 2.
Specificity of glutamate findings was assessed by additionally analyzing the ratios of NAA and choline vs creatine (Cr). In contrast to the glutamate/creatine ratio, the corresponding metric for the other metabolites was stable over time, and unaffected by treatment.
| Measure | Fa | df | p | mean (± SEM) | ||
|---|---|---|---|---|---|---|
| Acamprosate | Placebo | |||||
| NAA/Cr | 0.53 | 1, 31 | 0.47 | Scan 1 | 1.42 ± 0.04 | 1.41 ± 0.03 |
| Scan 2 | 1.50 ± 0.03 | 1.45 ± 0.03 | ||||
| Cho/Crb | 0.11 | 1, 30 | 0.78 | Scan 1 | 0.89 ± 0.04 | 0.88 ± 0.04 |
| Scan 2 | 0.87 ± 0.03 | 0.88 ± 0.03 | ||||
a
Results are presented for the time (scan 1 vs. scan 2) by treatment interaction effect. There were no significant main effects of time or treatment for either measure.
b
Analysis of the choline ratio included age as a covariate in the model, hence the different degrees of freedom.