Table 1.
Summary of IPA Ingenuity analysis for the upper, middle, and deep cortical zones
| IPA Ingenuity Pathway Analysis 317 GENES (ALL) | ||||
|---|---|---|---|---|
|
Diseases and Disorders |
p-value |
|
|
#genes |
| Neurological Disease |
2.40E-21 |
- |
1.99E-02 |
164 |
| Psychological Disorder |
3.15E-16 |
- |
1.99E-02 |
85 |
| Genetic Disorder |
7.48E-16 |
- |
1.99E-02 |
213 |
| Skeletal and Muscular Disorders |
3.73E-15 |
- |
1.99E-02 |
123 |
| Gastrointestinal Disorder |
8.25E-15 |
- |
1.99E-02 |
133 |
|
Molecular and Cellular Signaling |
p-value |
|
|
#genes |
| Cell-To-Cell Signaling and Interaction |
7.26E-20 |
- |
1.99E-02 |
68 |
| Cellular Assembly and Organization |
5.56E-16 |
- |
1.99E-02 |
82 |
| Cellular Movement |
1.28E-12 |
- |
1.99E-02 |
44 |
| Molecular Transport |
2.71E-07 |
- |
1.99E-02 |
67 |
| Small Molecule Biochemistry |
2.71E-07 |
- |
1.99E-02 |
54 |
|
Canonical Pathways |
p-value |
|
|
Ratio |
| Axonal Guidance Signaling |
1.26E-06 |
|
|
23/433 |
| CDK5 Signaling |
3.87E-05 |
|
|
9/94 |
| Cardiac b-adrenergic Signaling |
4.55E-05 |
|
|
11/154 |
| Corticotropin Releasing Hormone Signaling |
2.09E-04 |
|
|
9/136 |
| Dopamine Receptor Signaling |
6.05E-04 |
|
|
7/95 |
|
224 UPPER GENES |
|
|
|
|
|
Molecular and Cellular Signaling |
p-value |
|
|
#genes |
| Cell-To-Cell Signaling and Interaction |
4.31E-17 |
- |
2.12E-02 |
51 |
| Cellular Assembly and Organization |
3.34E-11 |
- |
2.12E-02 |
60 |
| Cellular Movement |
5.21E-10 |
- |
1.42E-02 |
35 |
| Cellular Function and Maintenance |
4.02E-08 |
- |
2.20E-02 |
49 |
| Molecular Transport |
4.02E-08 |
- |
1.75E-02 |
49 |
|
Canonical Pathways |
p-value |
|
|
Ratio |
| Corticotropin Releasing Hormone Signaling |
1.16E-04 |
|
|
8/136 |
| CDK5 Signaling |
1.76E-04 |
|
|
7/94 |
| Synaptic Long Term Depression |
1.62E-03 |
|
|
7/147 |
| Cardiac b-adrenergic Signaling |
2.35E-03 |
|
|
7/154 |
| Axonal Guidance Signaling |
2.65E-03 |
|
|
13/433 |
|
49 MID GENES |
|
|
|
|
|
Molecular and Cellular Signaling |
p-value |
|
|
#genes |
| Cellular Development |
9.09E-07 |
- |
4.47E-02 |
12 |
| Cell Morphology |
3.82E-06 |
- |
3.88E-02 |
16 |
| Cellular Assembly and Organization |
1.16E-05 |
- |
4.18E-02 |
16 |
| Cellular Movement |
4.59E-05 |
- |
4.76E-02 |
9 |
| Cell-To-Cell Signaling and Interaction |
4.00E-04 |
- |
4.76E-02 |
13 |
|
Canonical Pathways |
p-value |
|
|
Ratio |
| Axonal Guidance Signaling |
1.28E-07 |
|
|
10/433 |
| Semaphorin Signaling in Neurons |
1.54E-05 |
|
|
4/52 |
| Inositol Phosphate Metabolism |
7.95E-03 |
|
|
3/180 |
| CXCR4 Signaling |
9.66E-03 |
|
|
3/169 |
| Regulation of Actin-based Motility by Rho |
2.29E-02 |
|
|
2/91 |
|
44 DEEP GENES |
|
|
|
|
|
Molecular and Cellular Signaling |
p-value |
|
|
#genes |
| Carbohydrate Metabolism |
3.00E-05 |
- |
3.88E-02 |
7 |
| Molecular Transport |
3.00E-05 |
- |
3.88E-02 |
11 |
| Small Molecule Biochemistry |
3.00E-05 |
- |
4.34E-02 |
12 |
| DNA Replication, Recombination and Repair |
1.37E-04 |
- |
1.81E-02 |
2 |
| Nucleic Acid Metabolism |
1.37E-04 |
- |
2.32E-02 |
7 |
|
Canonical Pathways |
p-value |
|
|
Ratio |
| Protein Kinase A Signaling |
8.73E-05 |
|
|
6/328 |
| Cardiac b-adrenergic Signaling |
3.18E-04 |
|
|
4/154 |
| G-Protein Coupled Receptor Signaling |
1.43E-03 |
|
|
6/530 |
| cAMP-mediated signaling |
1.94E-03 |
|
|
4/219 |
| Synaptic Long Term Potentiation | 2.08E-03 | 3/114 | ||
In each panel the most salient “Molecular and Cellular Signaling” and “Canonical Pathways” categories are indicated, along with the associated p values. a, “all”. b, “upper group.” c, “middle group.” d, “deep group.”.